Regular Article PLATELETS AND THROMBOPOIESIS Clot retraction is mediated by factor XIII-dependent fibrin-aIIbb3- myosin axis in platelet sphingomyelin-rich membrane rafts
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چکیده
Clot retraction is mediated by factor XIII-dependent fibrin-aIIbb3myosin axis in platelet sphingomyelin-rich membrane rafts Kohji Kasahara, Mizuho Kaneda, Toshiaki Miki, Kazuko Iida, Naoko Sekino-Suzuki, Ikuo Kawashima, Hidenori Suzuki, Motoyuki Shimonaka, Morio Arai, Yoshiko Ohno-Iwashita, Soichi Kojima, Mitsuhiro Abe, Toshihide Kobayashi, Toshiro Okazaki, Masayoshi Souri, Akitada Ichinose, and Naomasa Yamamoto
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The rupture of atherosclerotic plaques leads to the exposure of matrix proteins, which in turn trigger arterial thrombosis, leading to stroke and cardiac infarction. Different platelet receptors sense the exposed matrix and induce platelet activation and secretion of prothrombotic molecules, leading to further platelet recruitment and finally thrombus formation. Integrins represent the major fa...
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Integrins engage in bidirectional signaling. Fibrinogen binding to integrins is regulated by inside-out signals initiated by agonist receptors, a process often called “integrin activation.” In turn, ligandbound integrins transduce outside-in signals to regulate cellular responses, among them cytoskeletal reorganization. In platelets, integrin aIIbb3 bidirectional signaling is required for effic...
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